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In Silico Exploration of Aryl Halides Analogues as Checkpoint Kinase 1 Inhibitors by Using 3D QSAR, Molecular Docking Study, and ADMET Screening

Purpose: In this review, a set of aryl halides analogs were identified as potent checkpoint kinase 1 (Chk1) inhibitors through a series of computer-aided drug design processes, to develop models with good predictive ability, highlight the important interactions between the ligand and the Chk1 recept...

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Bibliografske podrobnosti
izdano v:Adv Pharm Bull
Main Authors: Ghaleb, Adib, Aouidate, Adnane, Bouachrine, Mohammed, Lakhlifi, Tahar, Sbai, Abdelouhid
Format: Artigo
Jezik:Inglês
Izdano: Tabriz University of Medical Sciences 2019
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6468235/
https://ncbi.nlm.nih.gov/pubmed/31011562
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15171/apb.2019.011
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