Computer aided drug design based on 3D-QSAR and molecular docking studies of 5-(1H-indol-5-yl)-1,3,4-thiadiazol-2-amine derivatives as PIM2 inhibitors: a proposal to chemists

PIM2 kinase plays a crucial role in the cell cycle events including survival, proliferation, and differentiation in normal and neoplastic neuronal cells. Thus, it is regarded as an essential target for cancer pharmaceutical. Design of novel 5-(1H-indol-5-yl)-1,3,4-thiadiazol-2-amine derivatives with...

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Detalhes bibliográficos
Publicado no:In Silico Pharmacol
Main Authors: Aouidate, Adnane, Ghaleb, Adib, Ghamali, Mounir, Chtita, Samir, Ousaa, Abdellah, Choukrad, M’barek, Sbai, Abdelouahid, Bouachrine, Mohammed, Lakhlifi, Tahar
Formato: Artigo
Idioma:Inglês
Publicado em: Springer Berlin Heidelberg 2018
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6314742/
https://ncbi.nlm.nih.gov/pubmed/30607318
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s40203-018-0043-7
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