Priming of Adult Incision Response by Early-Life Injury: Neonatal Microglial Inhibition Has Persistent But Sexually Dimorphic Effects in Adult Rats

Neonatal hindpaw incision primes developing spinal nociceptive circuitry, resulting in enhanced hyperalgesia following reinjury in adulthood. Spinal microglia contribute to this persistent effect, and microglial inhibition at the time of adult reincision blocks the enhanced hyperalgesia. Here, we ph...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:J Neurosci
Päätekijät: Moriarty, Orla, Tu, YuShan, Sengar, Ameet S., Salter, Michael W., Beggs, Simon, Walker, Suellen M.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Society for Neuroscience 2019
Aiheet:
Research Articles
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC6468109/
https://ncbi.nlm.nih.gov/pubmed/30796159
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.1786-18.2019
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