Priming of Adult Incision Response by Early-Life Injury: Neonatal Microglial Inhibition Has Persistent But Sexually Dimorphic Effects in Adult Rats

Neonatal hindpaw incision primes developing spinal nociceptive circuitry, resulting in enhanced hyperalgesia following reinjury in adulthood. Spinal microglia contribute to this persistent effect, and microglial inhibition at the time of adult reincision blocks the enhanced hyperalgesia. Here, we ph...

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Spremljeno u:
Bibliografski detalji
Izdano u:J Neurosci
Glavni autori: Moriarty, Orla, Tu, YuShan, Sengar, Ameet S., Salter, Michael W., Beggs, Simon, Walker, Suellen M.
Format: Artigo
Jezik:Inglês
Izdano: Society for Neuroscience 2019
Teme:
Research Articles
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6468109/
https://ncbi.nlm.nih.gov/pubmed/30796159
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.1786-18.2019
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