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Maf deficiency in T cells dysregulates T(reg) - T(H)17 balance leading to spontaneous colitis
The maintenance of homeostasis in the gut is a major challenge for the immune system. Here we demonstrate that the transcription factor MAF plays a central role in T cells for the prevention of gastro-intestinal inflammation. Conditional knock out mice lacking Maf in all T cells developed spontaneou...
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| Udgivet i: | Sci Rep |
|---|---|
| Main Authors: | , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Nature Publishing Group UK
2019
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6468010/ https://ncbi.nlm.nih.gov/pubmed/30992496 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-42486-2 |
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