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The role of a small molecule in the modulation of cell death signal transduction pathways

Inflammasomes activate caspase-1 in response to molecular signals from pathogens and other danger stimuli as a part of the innate immune response. A previous study discovered a small-molecule, 4-fluoro-N’-[1-(2-pyridinyl)ethylidene]benzohydrazide, which we named DN1, that reduces the cytotoxicity of...

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Dades bibliogràfiques
Publicat a:ACS Infect Dis
Autors principals: Hartmann, Stella, Nusbaum, David J., Kim, Kevin, Alameh, Saleem, Ho, Chi-Lee C., Cruz, Renae L., Levitin, Anastasia, Bradley, Kenneth A., Martchenko, Mikhail
Format: Artigo
Idioma:Inglês
Publicat: 2018
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6467792/
https://ncbi.nlm.nih.gov/pubmed/30354048
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsinfecdis.8b00231
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