CHD1 loss alters AR binding at lineage-specific enhancers and modulates distinct transcriptional programs to drive prostate tumorigenesis

Deletion of the gene encoding the chromatin remodeler CHD1 is among the most common alterations in prostate cancer (PCa); however, the tumor suppressive functions of CHD1 and reasons for its tissue-specific loss remain undefined. We demonstrated that CHD1 occupied prostate-specific enhancers enriche...

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Udgivet i:Cancer Cell
Main Authors: Augello, Michael A., Liu, Deli, Deonarine, Lesa D., Robinson, Brian D., Huang, Dennis, Stelloo, Suzan, Blattner, Mirjam, Doane, Ashley S., Wong, Elissa W.P., Chen, Yu, Rubin, Mark A., Beltran, Himisha, Elemento, Olivier, Bergman, Andries M., Zwart, Wilbert, Sboner, Andrea, Dephoure, Noah, Barbieri, Christopher E.
Format: Artigo
Sprog:Inglês
Udgivet: 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6467783/
https://ncbi.nlm.nih.gov/pubmed/30930119
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2019.03.001
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