Exosome-enriched fractions from MS B cells induce oligodendrocyte death

OBJECTIVE: To identify whether factors toxic to oligodendrocytes (OLs), released by B cells from patients with MS, are found in extracellular microvesicles enriched in exosomes. METHODS: Conditioned medium (Sup) was obtained from cultures of blood B cells of patients with MS and normal controls (NCs...

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Pubblicato in:Neurol Neuroimmunol Neuroinflamm
Autori principali: Benjamins, Joyce A., Nedelkoska, Liljana, Touil, Hanane, Stemmer, Paul M., Carruthers, Nicholas J., Jena, Bhanu P., Naik, Akshata R., Bar-Or, Amit, Lisak, Robert P.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Lippincott Williams & Wilkins 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6467686/
https://ncbi.nlm.nih.gov/pubmed/31044144
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1212/NXI.0000000000000550
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