Inhibition of the deubiquitinase USP8 corrects a Drosophila PINK1 model of mitochondria dysfunction

Aberrant mitochondrial dynamics disrupts mitochondrial function and contributes to disease conditions. A targeted RNA interference screen for deubiquitinating enzymes (DUBs) affecting protein levels of multifunctional mitochondrial fusion protein Mitofusin (MFN) identified USP8 prominently influenci...

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Bibliografiske detaljer
Udgivet i:Life Sci Alliance
Main Authors: von Stockum, Sophia, Sanchez-Martinez, Alvaro, Corrà, Samantha, Chakraborty, Joy, Marchesan, Elena, Locatello, Lisa, Da Rè, Caterina, Cusumano, Paola, Caicci, Federico, Ferrari, Vanni, Costa, Rodolfo, Bubacco, Luigi, Rasotto, Maria Berica, Szabo, Ildiko, Whitworth, Alexander J, Scorrano, Luca, Ziviani, Elena
Format: Artigo
Sprog:Inglês
Udgivet: Life Science Alliance LLC 2019
Fag:
Research Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6467245/
https://ncbi.nlm.nih.gov/pubmed/30988163
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.26508/lsa.201900392
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