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Covalent Inhibitors of Plasmodium falciparum Glyceraldehyde 3-Phosphate Dehydrogenase with Antimalarial Activity in Vitro
[Image: see text] Covalent inhibitors of PfGAPDH characterized by a 3-bromoisoxazoline warhead were developed, and their mode of interaction with the target enzyme was interpreted by means of molecular modeling studies: some of them displayed a submicromolar antiplasmodial activity against both chlo...
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| 出版年: | ACS Med Chem Lett |
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| 主要な著者: | , , , , , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
American Chemical
Society
2019
|
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6466836/ https://ncbi.nlm.nih.gov/pubmed/30996801 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.8b00592 |
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