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Scaffold Morphing Approach To Expand the Toolbox of Broad-Spectrum Antivirals Blocking Dengue/Zika Replication
[Image: see text] We have recently discovered a family of 2,6-diaminopurine derivatives acting as DENV inhibitors by targeting an allosteric pocket on the thumb of the viral NS5 polymerase. Although the following target-based optimization allowed conversion of the hits into broad-spectrum DENV/ZIKV...
Gorde:
| Argitaratua izan da: | ACS Med Chem Lett |
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| Egile Nagusiak: | , , , , |
| Formatua: | Artigo |
| Hizkuntza: | Inglês |
| Argitaratua: |
American Chemical
Society
2019
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| Sarrera elektronikoa: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6466831/ https://ncbi.nlm.nih.gov/pubmed/30996796 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.8b00583 |
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