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Cellular Uptake of MCT1 Inhibitors AR-C155858 and AZD3965 and Their Effects on MCT-Mediated Transport of L-Lactate in Murine 4T1 Breast Tumor Cancer Cells

AR-C155858 and AZD3965, pyrrole pyrimidine derivatives, represent potent monocarboxylate transporter 1 (MCT1) inhibitors, with potential immunomodulatory and chemotherapeutic properties. Currently, there is limited information on the inhibitory properties of this new class of MCT1 inhibitors. The pu...

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Detalhes bibliográficos
Publicado no:AAPS J
Main Authors: Guan, Xiaowen, Rodriguez-Cruz, Vivian, Morris, Marilyn E.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6466617/
https://ncbi.nlm.nih.gov/pubmed/30617815
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1208/s12248-018-0279-5
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