SAR Studies and Biological Characterization of a Chromen-4-one Derivative as an Anti-Trypanosoma brucei Agent

[Image: see text] Chemical modulation of the flavonol 2-(benzo[d][1,3]dioxol-5-yl)-chromen-4-one (1), a promising anti-Trypanosomatid agent previously identified, was evaluated through a phenotypic screening approach. Herein, we have performed structure–activity relationship studies around hit compo...

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Vydáno v:ACS Med Chem Lett
Hlavní autoři: Borsari, Chiara, Santarem, Nuno, Macedo, Sara, Jiménez-Antón, María Dolores, Torrado, Juan J., Olías-Molero, Ana Isabel, Corral, María J., Tait, Annalisa, Ferrari, Stefania, Costantino, Luca, Luciani, Rosaria, Ponterini, Glauco, Gul, Sheraz, Kuzikov, Maria, Ellinger, Bernhard, Behrens, Birte, Reinshagen, Jeanette, Alunda, José María, Cordeiro-da-Silva, Anabela, Costi, Maria Paola
Médium: Artigo
Jazyk:Inglês
Vydáno: American Chemical Society 2019
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6466517/
https://ncbi.nlm.nih.gov/pubmed/30996791
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.8b00565
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