Investigation on 2′,3′-O-Substituted ATP Derivatives and Analogs as Novel P2X3 Receptor Antagonists

[Image: see text] Antagonists of the purinergic P2X3 receptors represent promising drugs for the treatment of inflammation and pain. The ATP derivative 2′,3′-O-(2,4,6-trinitrophenyl)-ATP (TNP-ATP) has been described as a potent competitive inhibitor of this receptor. In this work, the design and syn...

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Detalhes bibliográficos
Publicado no:ACS Med Chem Lett
Main Authors: Dal Ben, Diego, Buccioni, Michela, Lambertucci, Catia, Marucci, Gabriella, Spinaci, Andrea, Marchenkova, Anna, Abdelrahman, Aliaa, Nistri, Andrea, Müller, Christa E., Volpini, Rosaria
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2018
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6466514/
https://ncbi.nlm.nih.gov/pubmed/30996785
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.8b00524
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