SLC30A10 mutation involved in parkinsonism results in manganese accumulation within nano-vesicles of the Golgi apparatus

Manganese (Mn) is an essential metal that can be neurotoxic when elevated exposition occurs leading to parkinsonian-like syndromes. Mutations in the Slc30a10 gene have been identified in new forms of familial parkinsonism. SLC30A10 is a cell surface protein involved in the efflux of Mn protecting th...

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Veröffentlicht in:ACS Chem Neurosci
Hauptverfasser: Carmona, Asuncion, Zogzas, Charles E., Roudeau, Stéphane, Porcaro, Francesco, Garrevoet, Jan, Spiers, Kathryn M., Salomé, Murielle, Cloetens, Peter, Mukhopadhyay, Somshuvra, Ortega, Richard
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2018
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6465179/
https://ncbi.nlm.nih.gov/pubmed/30272946
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschemneuro.8b00451
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