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Labeling Single Domain Antibody Fragments with Fluorine-18 Using 2,3,5,6-Tetrafluorophenyl 6-[(18)F]Fluoronicotinate Resulting in High Tumor to Kidney Ratios

ImmunoPET agents are being investigated to assess the status of epidermal growth factor receptor 2 (HER2) in breast cancer patients with the goal of selecting those likely to benefit from HER2-targeted therapies and monitoring their progress after these treatments. We have been exploring the use of...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:Mol Pharm
Hauptverfasser: Zhou, Zhengyuan, McDougald, Darryl, Devoogdt, Nick, Zalutsky, Michael R., Vaidyanathan, Ganesan
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2018
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6465114/
https://ncbi.nlm.nih.gov/pubmed/30427188
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.molpharmaceut.8b00951
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