Hyperglycemia-driven Inhibition of AMP-Activated Protein Kinase α2 Induces Diabetic Cardiomyopathy by Promoting Mitochondria-associated Endoplasmic Reticulum Membranes in vivo

BACKGROUND: FUN14 domain containing 1 (Fundc1), an outer mitochondrial membrane protein, is important for mitophagy and mitochondria-associated endoplasmic reticulum (ER) membranes (MAMs). The roles of Fundc1 and MAMs in diabetic hearts remain unknown. The aims of this study therefore, were to deter...

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Dettagli Bibliografici
Pubblicato in:Circulation
Autori principali: Wu, Shengnan, Lu, Qiulun, Ding, Ye, Wu, Yin, Qiu, Yu, Wang, Pei, Mao, Xiaoxiang, Huang, Kai, Xie, Zhonglin, Zou, Ming-Hui
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6465113/
https://ncbi.nlm.nih.gov/pubmed/30646747
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCULATIONAHA.118.033552
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