Loss of SETD2 induces a metabolic switch in renal cell carcinoma cell lines toward enhanced oxidative phosphorylation

SETD2, a histone H3 lysine trimethyltransferase, is frequently inactivated and associated with recurrence of clear cell renal cell carcinoma (ccRCC). However, the impact of SETD2 loss on metabolic alterations in ccRCC is still unclear. In this study, SETD2 null isogenic 38E/38F clones derived from 7...

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Udgivet i:J Proteome Res
Main Authors: Liu, Jingping, Hanavan, Paul D., Kras, Katon, Ruiz, Yvette W., Castle, Erik P., Lake, Douglas F., Chen, Xianfeng, O’Brien, Daniel, Luo, Huijun, Robertson, Keith D., Gu, Haiwei, Ho, Thai H.
Format: Artigo
Sprog:Inglês
Udgivet: 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6465098/
https://ncbi.nlm.nih.gov/pubmed/30406665
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jproteome.8b00628
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