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Deployment of DNA polymerases beta and lambda in single-nucleotide and multinucleotide pathways of mammalian base excision DNA repair

There exist two major base excision DNA repair (BER) pathways, namely single-nucleotide or “short-patch” (SP-BER), and “long-patch” BER (LP-BER). Both pathways appear to be involved in the repair of small base lesions such as uracil, abasic sites and oxidized bases. In addition to DNA polymerase β (...

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Bibliographische Detailangaben
Veröffentlicht in:DNA Repair (Amst)
Hauptverfasser: Thapar, Upasna, Demple, Bruce
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2019
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6464370/
https://ncbi.nlm.nih.gov/pubmed/30763888
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.dnarep.2019.02.001
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