Inhibition of Cdk5 Promotes β-Cell Differentiation From Ductal Progenitors

Inhibition of notch signaling is known to induce differentiation of endocrine cells in zebrafish and mouse. After performing an unbiased in vivo screen of ∼2,200 small molecules in zebrafish, we identified an inhibitor of Cdk5 (roscovitine), which potentiated the formation of β-cells along the intra...

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Detalhes bibliográficos
Publicado no:Diabetes
Main Authors: Liu, Ka-Cheuk, Leuckx, Gunter, Sakano, Daisuke, Seymour, Philip A., Mattsson, Charlotte L., Rautio, Linn, Staels, Willem, Verdonck, Yannick, Serup, Palle, Kume, Shoen, Heimberg, Harry, Andersson, Olov
Formato: Artigo
Idioma:Inglês
Publicado em: American Diabetes Association 2018
Assuntos:
Islet Studies
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6463766/
https://ncbi.nlm.nih.gov/pubmed/28986398
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db16-1587
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