PDK4 Deficiency Suppresses Hepatic Glucagon Signaling by Decreasing cAMP Levels

In fasting or diabetes, gluconeogenic genes are transcriptionally activated by glucagon stimulation of the cAMP-protein kinase A (PKA)–CREB signaling pathway. Previous work showed pyruvate dehydrogenase kinase (PDK) inhibition in skeletal muscle increases pyruvate oxidation, which limits the availab...

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Detalhes bibliográficos
Publicado no:Diabetes
Main Authors: Park, Bo-Yoon, Jeon, Jae-Han, Go, Younghoon, Ham, Hye Jin, Kim, Jeong-Eun, Yoo, Eun Kyung, Kwon, Woong Hee, Jeoung, Nam-Ho, Jeon, Yong Hyun, Koo, Seung-Hoi, Kim, Byung-Gyu, He, Ling, Park, Keun-Gyu, Harris, Robert A., Lee, In-Kyu
Formato: Artigo
Idioma:Inglês
Publicado em: American Diabetes Association 2018
Assuntos:
Pathophysiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6463749/
https://ncbi.nlm.nih.gov/pubmed/30065033
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db17-1529
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