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PDK4 Deficiency Suppresses Hepatic Glucagon Signaling by Decreasing cAMP Levels
In fasting or diabetes, gluconeogenic genes are transcriptionally activated by glucagon stimulation of the cAMP-protein kinase A (PKA)–CREB signaling pathway. Previous work showed pyruvate dehydrogenase kinase (PDK) inhibition in skeletal muscle increases pyruvate oxidation, which limits the availab...
שמור ב:
| הוצא לאור ב: | Diabetes |
|---|---|
| Main Authors: | , , , , , , , , , , , , , , |
| פורמט: | Artigo |
| שפה: | Inglês |
| יצא לאור: |
American Diabetes Association
2018
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| נושאים: | |
| גישה מקוונת: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6463749/ https://ncbi.nlm.nih.gov/pubmed/30065033 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db17-1529 |
| תגים: |
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