Impact of amino acid substitutions at secondary structures in the BRCT domains of the tumor suppressor BRCA1: Implications for clinical annotation

Genetic testing for BRCA1, a DNA repair protein, can identify carriers of pathogenic variants associated with a substantially increased risk for breast and ovarian cancers. However, an association with increased risk is unclear for a large fraction of BRCA1 variants present in the human population....

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Dades bibliogràfiques
Publicat a:J Biol Chem
Autors principals: Fernandes, Vanessa C., Golubeva, Volha A., Di Pietro, Giuliano, Shields, Cara, Amankwah, Kwabena, Nepomuceno, Thales C., de Gregoriis, Giuliana, Abreu, Renata B. V., Harro, Carly, Gomes, Thiago T., Silva, Ricceli F., Suarez-Kurtz, Guilherme, Couch, Fergus J., Iversen, Edwin S., Monteiro, Alvaro N. A., Carvalho, Marcelo A.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2019
Matèries:
Protein Structure and Folding
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6463708/
https://ncbi.nlm.nih.gov/pubmed/30765603
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.005274
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