CEA expression heterogeneity and plasticity confer resistance to the CEA-targeting bispecific immunotherapy antibody cibisatamab (CEA-TCB) in patient-derived colorectal cancer organoids

BACKGROUND: The T cell bispecific antibody cibisatamab (CEA-TCB) binds Carcino-Embryonic Antigen (CEA) on cancer cells and CD3 on T cells, which triggers T cell killing of cancer cell lines expressing moderate to high levels of CEA at the cell surface. Patient derived colorectal cancer organoids (PD...

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Publicat a:J Immunother Cancer
Autors principals: Gonzalez-Exposito, Reyes, Semiannikova, Maria, Griffiths, Beatrice, Khan, Khurum, Barber, Louise J., Woolston, Andrew, Spain, Georgia, von Loga, Katharina, Challoner, Ben, Patel, Radhika, Ranes, Michael, Swain, Amanda, Thomas, Janet, Bryant, Annette, Saffery, Claire, Fotiadis, Nicos, Guettler, Sebastian, Mansfield, David, Melcher, Alan, Powles, Thomas, Rao, Sheela, Watkins, David, Chau, Ian, Matthews, Nik, Wallberg, Fredrik, Starling, Naureen, Cunningham, David, Gerlinger, Marco
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2019
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6463631/
https://ncbi.nlm.nih.gov/pubmed/30982469
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40425-019-0575-3
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