Evidence for DNA methylation mediating genetic liability to non-syndromic cleft lip/palate

AIM: To determine if nonsyndromic cleft lip with or without cleft palate (nsCL/P) genetic risk variants influence liability to nsCL/P through gene regulation pathways, such as those involving DNA methylation. MATERIALS & METHODS: nsCL/P genetic summary data and methylation data from four studies...

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Detalhes bibliográficos
Publicado no:Epigenomics
Main Authors: Howe, Laurence J, Richardson, Tom G, Arathimos, Ryan, Alvizi, Lucas, Passos-Bueno, Maria R, Stanier, Philip, Nohr, Ellen, Ludwig, Kerstin U, Mangold, Elisabeth, Knapp, Michael, Stergiakouli, Evie, Pourcain, Beate St, Smith, George Davey, Sandy, Jonathan, Relton, Caroline L, Lewis, Sarah J, Hemani, Gibran, Sharp, Gemma C
Formato: Artigo
Idioma:Inglês
Publicado em: Future Medicine Ltd 2019
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6462847/
https://ncbi.nlm.nih.gov/pubmed/30638414
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2217/epi-2018-0091
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