Loss of the tumor suppressor BIN1 enables ATM Ser/Thr kinase activation by the nuclear protein E2F1 and renders cancer cells resistant to cisplatin

The tumor suppressor bridging integrator 1 (BIN1) is a corepressor of the transcription factor E2F1 and inhibits cell-cycle progression. BIN1 also curbs cellular poly(ADP-ribosyl)ation (PARylation) and increases sensitivity of cancer cells to DNA-damaging therapeutic agents such as cisplatin. Howeve...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Folk, Watson P., Kumari, Alpana, Iwasaki, Tetsushi, Pyndiah, Slovénie, Johnson, Joanna C., Cassimere, Erica K., Abdulovic-Cui, Amy L., Sakamuro, Daitoku
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2019
Assuntos:
DNA and Chromosomes
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6462522/
https://ncbi.nlm.nih.gov/pubmed/30733337
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.005699
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