Mechanisms of Cisplatin-Induced Apoptosis and of Cisplatin Sensitivity: Potential of BIN1 to Act as a Potent Predictor of Cisplatin Sensitivity in Gastric Cancer Treatment

Cisplatin is the most important and efficacious chemotherapeutic agent for the treatment of advanced gastric cancer. Cisplatin forms inter- and intrastrand crosslinked DNA adducts and its cytotoxicity is mediated by propagation of DNA damage recognition signals to downstream pathways involving ATR,...

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Bibliographische Detailangaben
Hauptverfasser: Tanida, Satoshi, Mizoshita, Tsutomu, Ozeki, Keiji, Tsukamoto, Hironobu, Kamiya, Takeshi, Kataoka, Hiromi, Sakamuro, Daitoku, Joh, Takashi
Format: Artigo
Sprache:Inglês
Veröffentlicht: Hindawi Publishing Corporation 2012
Schlagworte:
Review Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3384945/
https://ncbi.nlm.nih.gov/pubmed/22778941
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2012/862879
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