PAM3 supports the generation of M2-like macrophages from lupus patient monocytes and improves disease outcome in murine lupus

Systematic Lupus Erythematosus (SLE) is an autoimmune syndrome of unclear etiology. While T and B cell abnormalities contribute to disease pathogenesis, recent work suggests that inflammatory M1-like macrophages also play a role. Previous work showed that the TLR2/1 agonist PAM3CSK4 (PAM3) could sti...

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Publicado en:J Autoimmun
Main Authors: Horuluoglu, Begum, Bayik, Defne, Kayraklioglu, Neslihan, Goguet, Emilie, Kaplan, Mariana J., Klinman, Dennis M.
Formato: Artigo
Idioma:Inglês
Publicado: 2019
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6462249/
https://ncbi.nlm.nih.gov/pubmed/30679006
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jaut.2019.01.004
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