Cysteinyl Leukotriene Receptor 2 Drives Lung Immunopathology Through a Platelet and High Mobility Box 1-Dependent Mechanism

Cysteinyl leukotrienes (cysLTs) facilitate eosinophilic mucosal type 2 immunopathology, especially in aspirin-exacerbated respiratory disease (AERD), by incompletely understood mechanisms. We now demonstrate that platelets, activated through the type 2 cysLT receptor (CysLT(2)R), cause IL-33-depende...

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Vydáno v:Mucosal Immunol
Hlavní autoři: Liu, Tao, Barrett, Nora A., Kanaoka, Yoshihide, Buchheit, Kathleen, Laidlaw, Tanya M., Garofalo, Denise, Lai, Juying, Katz, Howard R., Feng, Chunli, Boyce, Joshua A.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2019
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6462243/
https://ncbi.nlm.nih.gov/pubmed/30664709
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41385-019-0134-8
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