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Enzyme annotation for orphan and novel reactions using knowledge of substrate reactive sites
Thousands of biochemical reactions with characterized activities are “orphan,” meaning they cannot be assigned to a specific enzyme, leaving gaps in metabolic pathways. Novel reactions predicted by pathway-generation tools also lack associated sequences, limiting protein engineering applications. As...
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| Pubblicato in: | Proc Natl Acad Sci U S A |
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| Autori principali: | , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
National Academy of Sciences
2019
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6462048/ https://ncbi.nlm.nih.gov/pubmed/30910961 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1818877116 |
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