Oncoprotein HBXIP induces PKM2 via transcription factor E2F1 to promote cell proliferation in ER-positive breast cancer

We have reported that hepatitis B X-interacting protein (HBXIP, also termed LAMTOR5) can act as an oncogenic transcriptional co-activator to modulate gene expression, promoting breast cancer development. Pyruvate kinase muscle isozyme M2 (PKM2), encoded by PKM gene, has emerged as a key oncoprotein...

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Acta Pharmacol Sin
Egile Nagusiak: Liu, Bo-wen, Wang, Tian-jiao, Li, Lei-lei, Zhang, Lu, Liu, Yun-xia, Feng, Jin-yan, Wu, Yue, Xu, Fei-fei, Zhang, Quan-sheng, Bao, Ming-zhu, Zhang, Wei-ying, Ye, Li-hong
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Nature Publishing Group UK 2018
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC6462016/
https://ncbi.nlm.nih.gov/pubmed/29925919
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41401-018-0015-9
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