Lactate is an antidepressant that mediates resilience to stress by modulating the hippocampal levels and activity of histone deacetylases

Chronic stress promotes depression in some individuals, but has no effect in others. Susceptible individuals exhibit social avoidance and anxious behavior and ultimately develop depression, whereas resilient individuals live normally. Exercise counteracts the effects of stress. Our objective was to...

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Gepubliceerd in:Neuropsychopharmacology
Hoofdauteurs: Karnib, Nabil, El-Ghandour, Rim, El Hayek, Lauretta, Nasrallah, Patrick, Khalifeh, Mohamad, Barmo, Nour, Jabre, Vanessa, Ibrahim, Pascale, Bilen, Maria, Stephan, Joseph S., Holson, Edward B., Ratan, Rajiv R., Sleiman, Sama F.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Springer International Publishing 2019
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6461925/
https://ncbi.nlm.nih.gov/pubmed/30647450
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41386-019-0313-z
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