LncRNAs-directed PTEN enzymatic switch governs epithelial–mesenchymal transition

Despite the structural conservation of PTEN with dual-specificity phosphatases, there have been no reports regarding the regulatory mechanisms that underlie this potential dual-phosphatase activity. Here, we report that K27-linked polyubiquitination of PTEN at lysines 66 and 80 switches its phosphoi...

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Pubblicato in:Cell Res
Autori principali: Hu, Qingsong, Li, Chunlai, Wang, Shouyu, Li, Yajuan, Wen, Bo, Zhang, Yanyan, Liang, Ke, Yao, Jun, Ye, Youqiong, Hsiao, Heidi, Nguyen, Tina K., Park, Peter K., Egranov, Sergey D., Hawke, David H., Marks, Jeffrey R., Han, Leng, Hung, Mien-Chie, Zhang, Bing, Lin, Chunru, Yang, Liuqing
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6461864/
https://ncbi.nlm.nih.gov/pubmed/30631154
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41422-018-0134-3
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