Reduction in polyamine catabolism leads to spermine-mediated airway epithelial injury and induces asthma features

BACKGROUND: Airway epithelial injury is a crucial component of acute and severe asthma pathogenesis and a promising target for treatment of refractory asthma. However, the underlying mechanism of epithelial injury remains poorly explored. Though high levels of polyamines, mainly spermine, have been...

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Bibliographic Details
Published in:Allergy
Main Authors: Jain, Vaibhav, Raina, Shikha, Gheware, Atish Prabhakar, Singh, Rita, Rehman, Rakhshinda, Negi, Vinny, Stewart, Tracy Murray, Mabalirajan, Ulaganathan, Mishra, Adarsh Kumar, Casero, Robert A., Agrawal, Anurag, Ghosh, Balaram
Format: Artigo
Language:Inglês
Published: 2018
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6461714/
https://ncbi.nlm.nih.gov/pubmed/29729200
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/all.13472
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