The Enhanced Tumor Specificity of TG6002, an Armed Oncolytic Vaccinia Virus Deleted in Two Genes Involved in Nucleotide Metabolism

Oncolytic vaccinia viruses are currently in clinical development. However, the safety and the tumor selectivity of these oncolytic viruses must be improved. We previously constructed a first-generation oncolytic vaccinia virus by expressing the suicide gene FCU1 inserted in the J2R locus that encode...

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Vydáno v:Mol Ther Oncolytics
Hlavní autoři: Foloppe, Johann, Kempf, Juliette, Futin, Nicolas, Kintz, Jacqueline, Cordier, Pascale, Pichon, Christelle, Findeli, Annie, Vorburger, Fabien, Quemeneur, Eric, Erbs, Philippe
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Gene & Cell Therapy 2019
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6461584/
https://ncbi.nlm.nih.gov/pubmed/31011628
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omto.2019.03.005
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