Safety, biodistribution and viral shedding of oncolytic vaccinia virus TG6002 administered intravenously in healthy beagle dogs

Oncolytic virotherapy is an emerging strategy that uses replication-competent viruses to kill tumor cells. We have reported the oncolytic effects of TG6002, a recombinant oncolytic vaccinia virus, in preclinical human xenograft models and canine tumor explants. To assess the safety, biodistribution...

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Bibliographic Details
Published in:Sci Rep
Main Authors: Béguin, Jérémy, Gantzer, Murielle, Farine, Isabelle, Foloppe, Johann, Klonjkowski, Bernard, Maurey, Christelle, Quéméneur, Éric, Erbs, Philippe
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2021
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7838210/
https://ncbi.nlm.nih.gov/pubmed/33500518
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-021-81831-2
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