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Targeted Inhibition of Plasmodium falciparum Calcium-Dependent Protein Kinase 1 with a Constrained J Domain-Derived Disruptor Peptide
To explore the possibility of constrained peptides to target Plasmodium-infected cells, we designed a J domain mimetic derived from Plasmodium falciparum calcium-dependent protein kinase 1 (Pf CDPK1) as a strategy to disrupt J domain binding and inhibit Pf CDPK1 activity. The J domain disruptor (JDD...
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| Pubblicato in: | ACS Infect Dis |
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| Autori principali: | , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2019
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6461495/ https://ncbi.nlm.nih.gov/pubmed/30746930 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsinfecdis.8b00347 |
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