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Progesterone receptor integrates the effects of mutated MED12 and altered DNA methylation to stimulate RANKL expression and stem cell proliferation in uterine leiomyoma

Progesterone and its receptor, PR, are essential for uterine leiomyoma (LM, a.k.a., fibroid) tumorigenesis, but the underlying cellular and molecular mechanisms remain unclear. The receptor activator of NF-κB (RANKL) was recently identified as a novel progesterone/PR-responsive gene that plays an im...

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Détails bibliographiques
Publié dans:Oncogene
Auteurs principaux: Liu, Shimeng, Yin, Ping, Kujawa, Stacy A., Coon, John S., Okeigwe, Ijeoma, Bulun, Serdar E.
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group UK 2018
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6461478/
https://ncbi.nlm.nih.gov/pubmed/30538295
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41388-018-0612-6
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