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Characterization of MenA (isoprenyl diphosphate:1,4-dihydroxy-2-naphthoate isoprenyltransferase) from Mycobacterium tuberculosis

The menaquinone biosynthetic pathway presents a promising drug target against Mycobacterium tuberculosis and potentially other Gram-positive pathogens. In the present study, the essentiality, steady state kinetics of MenA from M. tuberculosis and the mechanism of MenA inhibition by Ro 48–8071 were c...

詳細記述

保存先:
書誌詳細
出版年:PLoS One
主要な著者: Dhiman, Rakesh K., Pujari, Venugopal, Kincaid, James M., Ikeh, Melanie A., Parish, Tanya, Crick, Dean C.
フォーマット: Artigo
言語:Inglês
出版事項: Public Library of Science 2019
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC6461227/
https://ncbi.nlm.nih.gov/pubmed/30978223
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0214958
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