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RNA as a key factor in driving or preventing self-assembly of the TAR DNA-binding protein 43
Amyotrophic lateral sclerosis and frontotemporal lobar degeneration are incurable motor neuron diseases associated with muscle weakness, paralysis and respiratory failure. Accumulation of TAR DNA-binding protein 43 (TDP-43) as toxic cytoplasmic inclusions is one of the hallmarks of these pathologies...
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| Pubblicato in: | J Mol Biol |
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| Autori principali: | , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Elsevier
2019
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6461199/ https://ncbi.nlm.nih.gov/pubmed/30742796 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2019.01.028 |
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