Exosomes from N-Myc amplified neuroblastoma cells induce migration and confer chemoresistance to non-N-Myc amplified cells: implications of intra-tumour heterogeneity

Neuroblastoma accounts for 15% of childhood cancer mortality. Amplification of the oncogene N-Myc is a well-established poor prognostic marker for neuroblastoma. Whilst N-Myc amplification status strongly correlates with higher tumour aggression and resistance to treatment, the role of N-Myc in the...

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Veröffentlicht in:J Extracell Vesicles
Hauptverfasser: Fonseka, Pamali, Liem, Michael, Ozcitti, Cemil, Adda, Christopher G., Ang, Ching-Seng, Mathivanan, Suresh
Format: Artigo
Sprache:Inglês
Veröffentlicht: Taylor & Francis 2019
Schlagworte:
Short Communication
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6461098/
https://ncbi.nlm.nih.gov/pubmed/31007876
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/20013078.2019.1597614
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