Mitochondrial Defunctionalization Supresses Tim-3-Galectin-9 Secretory Pathway in Human Colorectal Cancer Cells and Thus Can Possibly Affect Tumor Immune Escape

The Tim-3-galectin-9 secretory pathway is known to protect various types of cancer cells against host immune surveillance. We found that pharmacologically induced mitochondrial dysfunction leads to a reduced galectin-9 expression/exocytosis in human colorectal cancer cells and re-distribution of thi...

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Detalhes bibliográficos
Publicado no:Front Pharmacol
Main Authors: Sakhnevych, Svetlana S., Yasinska, Inna M., Fasler-Kan, Elizaveta, Sumbayev, Vadim V.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2019
Assuntos:
Pharmacology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6461007/
https://ncbi.nlm.nih.gov/pubmed/31024310
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2019.00342
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