FKBPL and its peptide derivatives inhibit endocrine therapy resistant cancer stem cells and breast cancer metastasis by downregulating DLL4 and Notch4

BACKGROUND: Optimising breast cancer treatment remains a challenge. Resistance to therapy is a major problem in both ER- and ER+ breast cancer. Tumour recurrence after chemotherapy and/or targeted therapy leads to more aggressive tumours with enhanced metastatic ability. Self-renewing cancer stem ce...

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Detalhes bibliográficos
Publicado no:BMC Cancer
Main Authors: McClements, Lana, Annett, Stephanie, Yakkundi, Anita, O’Rourke, Martin, Valentine, Andrea, Moustafa, Nermeen, Alqudah, Abdelrahim, Simões, Bruno M., Furlong, Fiona, Short, Amy, McIntosh, Stuart A., McCarthy, Helen O., Clarke, Robert B., Robson, Tracy
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2019
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6460676/
https://ncbi.nlm.nih.gov/pubmed/30975104
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-019-5500-0
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