Repurposing the selective estrogen receptor modulator bazedoxifene to suppress gastrointestinal cancer growth

Excessive signaling through gp130, the shared receptor for the interleukin (IL)6 family of cytokines, is a common hallmark in solid malignancies and promotes their progression. Here, we established the in vivo utility of bazedoxifene, a steroid analog clinically approved for the treatment of osteopo...

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Sparad:
Bibliografiska uppgifter
I publikationen:EMBO Mol Med
Huvudupphovsmän: Thilakasiri, Pathum, Huynh, Jennifer, Poh, Ashleigh R, Tan, Chin Wee, Nero, Tracy L, Tran, Kelly, Parslow, Adam C, Afshar‐Sterle, Shoukat, Baloyan, David, Hannan, Natalie J, Buchert, Michael, Scott, Andrew Mark, Griffin, Michael DW, Hollande, Frederic, Parker, Michael W, Putoczki, Tracy L, Ernst, Matthias, Chand, Ashwini L
Materialtyp: Artigo
Språk:Inglês
Publicerad: John Wiley and Sons Inc. 2019
Ämnen:
Research Articles
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6460354/
https://ncbi.nlm.nih.gov/pubmed/30885958
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/emmm.201809539
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