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Diverse small molecules prevent macrophage lysis during pyroptosis

Pyroptosis is a programmed process of proinflammatory cell death mediated by caspase-1-related proteases that cleave the pore-forming protein, gasdermin D, causing cell lysis and release of inflammatory intracellular contents. The amino acid glycine prevents pyroptotic lysis via unknown mechanisms,...

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Bibliografische gegevens
Gepubliceerd in:Cell Death Dis
Hoofdauteurs: Loomis, Wendy P., den Hartigh, Andreas B., Cookson, Brad T., Fink, Susan L.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Publishing Group UK 2019
Onderwerpen:
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6459844/
https://ncbi.nlm.nih.gov/pubmed/30975978
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-019-1559-4
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