Gasdermin pores permeabilize mitochondria to augment caspase-3 activation during apoptosis and inflammasome activation

Gasdermin E (GSDME/DFNA5) cleavage by caspase-3 liberates the GSDME-N domain, which mediates pyroptosis by forming pores in the plasma membrane. Here we show that GSDME-N also permeabilizes the mitochondrial membrane, releasing cytochrome c and activating the apoptosome. Cytochrome c release and cas...

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Detaylı Bibliyografya
Yayımlandı:Nat Commun
Asıl Yazarlar: Rogers, Corey, Erkes, Dan A., Nardone, Alexandria, Aplin, Andrew E., Fernandes-Alnemri, Teresa, Alnemri, Emad S.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Nature Publishing Group UK 2019
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6459836/
https://ncbi.nlm.nih.gov/pubmed/30976076
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-09397-2
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