Genomic Reorganization of Lamin-Associated Domains in Cardiac Myocytes is Associated with Differential Gene Expression and DNA Methylation in Human Dilated Cardiomyopathy

RATIONALE: Lamin A/C (LMNA), a nuclear membrane protein, interacts with genome through lamin-associated domains (LADs) and regulates gene expression. Mutations in the LMNA gene cause a diverse array of diseases, including dilated cardiomyopathy (DCM). DCM is the leading cause of death in laminopathi...

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Udgivet i:Circ Res
Main Authors: Cheedipudi, Sirisha Marreddy, Matkovich, Scot J., Coarfa, Cristian, Hu, Xin, Robertson, Matthew J., Sweet, Mary, Taylor, Matthew, Mestroni, Luisa, Cleveland, Joseph, Willerson, James T., Gurha, Priyatansh, Marian, Ali J.
Format: Artigo
Sprog:Inglês
Udgivet: 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6459729/
https://ncbi.nlm.nih.gov/pubmed/30739589
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.118.314177
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