DNA Damage Response/TP53 Pathway Is Activated and Contributes to the Pathogenesis of Dilated Cardiomyopathy Associated with Lamin A/C Mutations

RATIONALE: Mutations in the LMNA gene, encoding lamin A/C (LMNA), are responsible for laminopathies. Dilated cardiomyopathy (DCM) is a major cause of mortality and morbidity in laminopathies. OBJECTIVE: To gain insights into the molecular pathogenesis of DCM in laminopathies. METHODS AND RESULTS: We...

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Publicado no:Circ Res
Main Authors: Chen, Suet Nee, Lombardi, Raffaella, Karmouch, Jennifer, Tsai, Ju-Yun, Czernuszewicz, Grace, Taylor, Matthew R.G., Mestroni, Luisa, Coarfa, Cristian, Gurha, Priyatansh, Marian, Ali J
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6460911/
https://ncbi.nlm.nih.gov/pubmed/30696354
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.118.314238
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