Structure-Based Design of MptpB Inhibitors That Reduce Multidrug-Resistant Mycobacterium tuberculosis Survival and Infection Burden in Vivo

[Image: see text] Mycobacterium tuberculosis protein-tyrosine-phosphatase B (MptpB) is a secreted virulence factor that subverts antimicrobial activity in the host. We report here the structure-based design of selective MptpB inhibitors that reduce survival of multidrug-resistant tuberculosis strain...

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Detalhes bibliográficos
Publicado no:J Med Chem
Main Authors: Vickers, Clare F., Silva, Ana P. G., Chakraborty, Ajanta, Fernandez, Paulina, Kurepina, Natalia, Saville, Charis, Naranjo, Yandi, Pons, Miquel, Schnettger, Laura S., Gutierrez, Maximiliano G., Park, Steven, Kreiswith, Barry N., Perlin, David S., Thomas, Eric J., Cavet, Jennifer S., Tabernero, Lydia
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2018
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6459586/
https://ncbi.nlm.nih.gov/pubmed/30153005
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.8b00832
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