Quantitative mapping of DNA phosphorothioatome reveals phosphorothioate heterogeneity of low modification frequency

Phosphorothioate (PT) modifications of the DNA backbone, widespread in prokaryotes, are first identified in bacterial enteropathogens Escherichia coli B7A more than a decade ago. However, methods for high resolution mapping of PT modification level are still lacking. Here, we developed the PT-IC-seq...

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Bibliografske podrobnosti
izdano v:PLoS Genet
Main Authors: Li, Jinli, Chen, Yi, Zheng, Tao, Kong, Lingxin, Zhu, Sucheng, Sun, Yihua, Deng, Zixin, Yang, Litao, You, Delin
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2019
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6459556/
https://ncbi.nlm.nih.gov/pubmed/30933976
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1008026
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