Intestinal TGR5 agonism improves hepatic steatosis and insulin sensitivity in Western diet-fed mice

Takeda G protein-coupled receptor 5 (TGR5) agonists induce systemic release of glucagon-like peptides (GLPs) from intestinal L cells, a potentially therapeutic action against metabolic diseases such as nonalcoholic steatohepatitis (NASH), nonalcoholic fatty liver disease (NAFLD), and Type 2 diabetes...

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Udgivet i:Am J Physiol Gastrointest Liver Physiol
Main Authors: Finn, Patricia D., Rodriguez, David, Kohler, Jill, Jiang, Zhengfeng, Wan, Sindy, Blanco, Erick, King, Andrew J., Chen, Tao, Bell, Noah, Dragoli, Dean, Jacobs, Jeffrey W., Jain, Rakesh, Leadbetter, Michael, Siegel, Matthew, Carreras, Christopher W., Koo-McCoy, Samantha, Shaw, Karen, Le, Cathy, Vanegas, Sandra, Hsu, I-Hsin, Kozuka, Kenji, Okamoto, Keiko, Caldwell, Jeremy S., Lewis, Jason G.
Format: Artigo
Sprog:Inglês
Udgivet: American Physiological Society 2019
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6459286/
https://ncbi.nlm.nih.gov/pubmed/30605011
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpgi.00300.2018
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